Differential regulation of the c-Myc/Lin28 axis discriminates subclasses of rearranged MLL leukemia.

ABSTRACT: MLL rearrangements occur in myeloid and lymphoid leukemias and are generally associated with a poor prognosis, however this varies depending on the fusion partner. We modeled acute myeloid leukemia (AML) in mice using various MLL fusion proteins (MLL-FPs) and observed significantly different survival outcomes. To better understand the differences between these leukemias, we examined the genome wide expression profiles of leukemic cells transformed with different MLL-FPs. RNA-sequencing and pathway analysis identified the c-Myc transcriptional program as one of the top distinguishing features. c-Myc protein levels were highly correlative with AML disease latency in mice. Functionally, overexpression of c-Myc resulted in a more aggressive proliferation rate in MLL-FP cell lines. While all ML

SUBMITTER: Chen L 

PROVIDER: S-EPMC5041898 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature