Association of genetic variants in lncRNA H19 with risk of colorectal cancer in a Chinese population.

ABSTRACT:

Objective

The long non-coding RNA (lncRNA) gene, H19, has been involving in multiple biological functions, which also plays a vital role in colorectal cancer carcinogenesis. However, the association between genetic variants in H19 and colorectal cancer susceptibility has not been reported. In this study, we aim to explore whether H19 polymorphisms are related to the susceptibility of colorectal cancer.

Methods

We conducted a case-control study to evaluate the association between four selected single nucleotide polymorphisms (SNPs) (rs2839698, rs3024270, rs217727, and rs2735971) in H19 and the risk of colorectal cancer in a Chinese population.

Results

We found that individuals with rs2839698 A allele had a significantly increased risk of colorectal cancer, compared to

SUBMITTER: Li S 

PROVIDER: S-EPMC5041918 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature