Critical role of DEK and its regulation in tumorigenesis and metastasis of hepatocellular carcinoma.

ABSTRACT: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality globally. Therefore, it is quite essential to identify novel HCC-related molecules for the discovery of new prognostic markers and therapeutic targets. As an oncogene, DEK plays an important role in cell processes and participates in a variety of cellular metabolic functions, and its altered expression is associated with several human malignancies. However, the functional significance of DEK and the involved complex biological events in HCC development and progression are poorly understood. Here, combing the results from clinical specimens and cultured cell lines, we uncover a critical oncogenic role of DEK, which is highly expressed in HCC cells. DEK protein encompasses two isoforms (isoforms 1 and 2)

SUBMITTER: Yu L 

PROVIDER: S-EPMC5042019 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature