Association between in utero zidovudine exposure and nondefect adverse birth outcomes: analysis of prospectively collected data from the Antiretroviral Pregnancy Registry.

ABSTRACT:

Objective

To examine the association between nondefect adverse birth outcomes and in utero exposure to zidovudine (ZDV)-containing regimens versus non-ZDV antiretroviral (ARV) regimens.

Design

Analysis of prospectively-collected data.

Setting

Global.

Population

HIV-infected pregnant women prenatally exposed to antiretrovirals.

Methods

Estimation of prevalence of and risk for nondefect adverse birth outcomes among HIV-infected women.

Main outcome measures

Prevalence of and risk for nondefect adverse birth outcomes.

Results

Among 12 780 singleton birth outcomes with in utero ZDV exposure, 96.1% were live births; 3.9% were spontaneous abortions, induced abortions or stillbirths. Among live births, 16.4% were low birthweight (LBW); 12.3% were p

SUBMITTER: Vannappagari V 

PROVIDER: S-EPMC5042033 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature