Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies.

ABSTRACT:

Background

Follicular helper T (TFH) cells underpin T cell-dependent humoral immunity and the success of most vaccines. TFH cells also contribute to human immune disorders, such as autoimmunity, immunodeficiency, and malignancy. Understanding the molecular requirements for the generation and function of TFH cells will provide strategies for targeting these cells to modulate their behavior in the setting of these immunologic abnormalities.

Objective

We sought to determine the signaling pathways and cellular interactions required for the development and function of TFH cells in human subjects.

Methods

Human primary immunodeficiencies (PIDs) resulting from monogenic mutations provide a unique opportunity to assess the requirement for particular molecules in regulating hu

SUBMITTER: Ma CS 

PROVIDER: S-EPMC5042203 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature