Systematic review and meta-analysis: Small intestinal bacterial overgrowth in chronic pancreatitis.

ABSTRACT:

Background

Evidence on small intestinal bacterial overgrowth (SIBO) in patients with chronic pancreatitis (CP) is conflicting.

Aim

The purpose of this study was to perform a systematic review and meta-analysis on the prevalence of SIBO in CP and to examine the relationship of SIBO with symptoms and nutritional status.

Methods

Case-control and cross-sectional studies investigating SIBO in CP patients were analysed. The prevalence of positive tests was pooled across studies, and the rate of positivity between CP cases and controls was calculated.

Results

In nine studies containing 336 CP patients, the pooled prevalence of SIBO was 36% (95% confidence interval (CI) 17-60%) with considerable heterogeneity (I²= 91%). A sensitivity analysis excludi

SUBMITTER: Capurso G 

PROVIDER: S-EPMC5042309 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature