RNA-Seq Transcriptome Analysis of Direction-Selective T4/T5 Neurons in Drosophila.

ABSTRACT: Neuronal computation underlying detection of visual motion has been studied for more than a half-century. In Drosophila, direction-selective T4/T5 neurons show supralinear signal amplification in response to stimuli moving in their preferred direction, in agreement with the prediction made by the Hassenstein-Reichardt detector. Nevertheless, the molecular mechanism explaining how the Hassenstein-Reichardt model is implemented in T4/T5 cells has not been identified yet. In the present study, we utilized cell type-specific transcriptome profiling with RNA-seq to obtain a complete gene expression profile of T4/T5 neurons. We analyzed the expression of genes that affect neuronal computational properties and can underlie the molecular implementation of the core features of the Hassenstein-Reich

SUBMITTER: Pankova K 

PROVIDER: S-EPMC5042512 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature