Serum Interleukin-18 and Its Gene Haplotypes Profile as Predictors in Patients with Diabetic Nephropathy.

ABSTRACT:

Background

Diabetic nephropathy (DN) is known as an acute microvascular complexity as a subsequence progression in diabetes mellitus type 1 and 2. Many evidence pointed that the proinflammatory cytokine Interleukin (IL)-18 might be involved in the pathogenesis of DN.

Aim

The current study aimed to evaluate the association of serum IL-18 and its promoter gene polymorphisms with diabetic nephropathy.

Methods

This study included 62 diabetic nephropathy patients (DN group) compared to 52 diabetes mellitus patients (DM group). The two groups were subjected to anthropometry assessment, molecular studies including SNP genotyping by RFLP and finally statistical analysis.

Results

The assessment of the serum IL-18 level and the frequencies of its allele and haplotype:

SUBMITTER: Elneam AI 

PROVIDER: S-EPMC5042610 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature