Pragmatic Clinical Trials in CKD: Opportunities and Challenges.

ABSTRACT: Randomized controlled trials in CKD lag in number behind those of other chronic diseases, despite the high morbidity and mortality experienced by patients with kidney disease and the exorbitant costs of their health care. Observational studies of CKD frequently yield seemingly paradoxic associations of traditional risk factors with outcomes, making it difficult to extrapolate the results of trials conducted in people with normal kidney function to patients with CKD. However, many completed trials in CKD have been limited by intermediate outcomes of unclear clinical significance or narrow eligibility criteria that limit external validity, and implementation of proven therapies remains a challenge. It is therefore imperative that the nephrology community capitalize on recent interest in nove

SUBMITTER: de Boer IH 

PROVIDER: S-EPMC5042675 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature