Proton Pump Inhibitors and Risk of Incident CKD and Progression to ESRD.

ABSTRACT: The association between proton pump inhibitors (PPI) use and risk of acute interstitial nephritis has been described. However, whether exposure to PPI associates with incident CKD, CKD progression, or ESRD is not known. We used Department of Veterans Affairs national databases to build a primary cohort of new users of PPI (n=173,321) and new users of histamine H₂-receptor antagonists (H₂ blockers; n=20,270) and followed these patients over 5 years to ascertain renal outcomes. In adjusted Cox survival models, the PPI group, compared with the H₂ blockers group, had an increased risk of incident eGFR<60 ml/min per 1.73 m² and of incident CKD (hazard ratio [HR], 1.22; 95% confidence interval [95% CI], 1.18 to 1.26; and HR, 1.28; 95% CI, 1.23 to 1.34,

SUBMITTER: Xie Y 

PROVIDER: S-EPMC5042677 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature