Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer's disease.

ABSTRACT: The lack of strong association between brain beta-amyloid deposition and cognitive impairment has been a challenge for the Alzheimer's disease (AD) field. Although beta-amyloid is necessary for the pathologic diagnosis of AD, it is not sufficient to make the pathologic diagnosis or cause dementia. We sought to identify the genetic modifiers of the relation between cortical beta-amyloid burden (measured using [¹⁸F]Florbetapir-PET) and cognitive dysfunction (measured using ADAS-cog) by conducting a genome-wide interaction study on baseline data from participants in the Alzheimer's Disease Neuroimaging Initiative (ADNI) phases GO/2 (n=678). Near genome-wide significant interaction effect was observed for rs73069071 within the IAPP (amylin) and SLCO1A2 genes (P=6.2 × 10^-8

SUBMITTER: Roostaei T 

PROVIDER: S-EPMC5042808 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature