Epithelial Regeneration After Gastric Ulceration Causes Prolonged Cell-Type Alterations.

ABSTRACT:

Background & aims

The peptic ulcer heals through a complex process, although the ulcer relapse often occurs several years later after healing. Our hypothesis is that even after visual evidence of healing of gastric ulceration, the regenerated epithelium is aberrant for an extended interval, increasing susceptibility of the regenerated epithelium to damage and further diseases.

Methods

Gastric ulcers were induced in mice by serosal topical application of acetic acid.

Results

Gastric ulcers induced by acetic acid visually healed within 30 days. However, regenerated epithelial architecture was poor. The gene profile of regenerated tissue was abnormal, indicating increased stem/progenitor cells, deficient differentiated gastric cell types, and deranged cell homeostasis. D

SUBMITTER: Aihara E 

PROVIDER: S-EPMC5042868 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature