Controlling the strontium-doping in calcium phosphate microcapsules through yeast-regulated biomimetic mineralization.

ABSTRACT: Yeast cells have controllable biosorption on metallic ions during metabolism. However, few studies were dedicated to using yeast-regulated biomimetic mineralization process to control the strontium-doped positions in calcium phosphate microcapsules. In this study, the yeast cells were allowed to pre-adsorb strontium ions metabolically and then served as sacrificing template for the precipitation and calcination of mineral shell. The pre-adsorption enabled the microorganism to enrich of strontium ions into the inner part of the microcapsules, which ensured a slow-release profile of the trace element from the microcapsule. The co-culture with human marrow stromal cells showed that gene expressions of alkaline phosphatase and Collagen-I were promoted. The promotion of osteogenic differentiati

SUBMITTER: Huang M 

PROVIDER: S-EPMC5043151 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature