Factors associated with response to clozapine in schizophrenia: a review.

ABSTRACT:

Background

Clozapine has been serving as the gold standard medication for patients with treatment-resistant schizophrenia who failed to respond to other antipsychotics. However, factors affecting response to this medication have not been comprehensively reviewed recently.

Methods

In order to find factors associated with response to clozapine in schizophrenia, a literature search was conducted using PubMed through January 2011 with keywords of clozapine, response, and schizophrenia. Cross-referencing of relevant articles was also performed. Factors were arbitrarily classified into the following: demographic/clinical, oral dosage/pharmacokinetic, biochemical, (electro)physiological, genetic, imaging, and combinations.

Results

A synthesis from 280 articles indicated that

SUBMITTER: Suzuki T 

PROVIDER: S-EPMC5044555 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature