ISN Forefronts Symposium 2015: The Evolution of Hypertension-Old Genes, New Concepts.

ABSTRACT: Hypertension is known as the "silent killer," driving the global public health burden of cardiovascular and renal disease. Blood pressure homeostasis is intimately associated with sodium balance and the distribution of sodium between fluid compartments and within tissues. On a population level, most societies consume 10 times more salt that the 0.5 g required by physiological need. This high salt intake is strongly linked to hypertension and to the World Health Organization targeting a ∼30% relative reduction in mean population salt intake to arrest the global mortality due to cardiovascular disease. But how does a habitually high-salt diet cause blood pressure to rise? In this focused review, we discuss 2 "evolutionary medicine" concepts, presented at the ISN Forefront Meeting "Immunomodu

SUBMITTER: Mansley MK 

PROVIDER: S-EPMC5044930 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature