Ontology highlight
ABSTRACT:
SUBMITTER: Wang A
PROVIDER: S-EPMC5045383 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Oncotarget 20160501 20
The FLT3-ITD mutation is one of the most prevalent oncogenic mutations in AML. Several FLT3 kinase inhibitors have shown impressive activity in clinical evaluation, however clinical responses are usually transient and clinical effects are rapidly lost due to drug resistance. One of the resistance mechanisms in the AML refractory patients involves FLT3-ligand induced reactivation of AKT and/or ERK signaling via FLT3 wt kinase. Via a screen of numerous AKT kinase inhibitors, we identified the well ...[more]