Functional inclusion bodies produced in the yeast Pichia pastoris.

ABSTRACT:

Background

Bacterial inclusion bodies (IBs) are non-toxic protein aggregates commonly produced in recombinant bacteria. They are formed by a mixture of highly stable amyloid-like fibrils and releasable protein species with a significant extent of secondary structure, and are often functional. As nano structured materials, they are gaining biomedical interest because of the combination of submicron size, mechanical stability and biological activity, together with their ability to interact with mammalian cell membranes for subsequent cell penetration in absence of toxicity. Since essentially any protein species can be obtained as IBs, these entities, as well as related protein clusters (e.g., aggresomes), are being explored in biocatalysis and in biomedicine as mechanically stable so

SUBMITTER: Rueda F 

PROVIDER: S-EPMC5045588 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature