Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer.

ABSTRACT: Tumor heterogeneity may reduce the efficacy of molecularly guided systemic therapy for cancers that have metastasized. To determine whether the genomic alterations in a single metastasis provide a reasonable assessment of the major oncogenic drivers of other dispersed metastases in an individual, we analyzed multiple tumors from men with disseminated prostate cancer through whole-exome sequencing, array comparative genomic hybridization (CGH) and RNA transcript profiling, and we compared the genomic diversity within and between individuals. In contrast to the substantial heterogeneity between men, there was limited diversity among metastases within an individual. The number of somatic mutations, the burden of genomic copy number alterations and aberrations in known oncogenic drivers were a

SUBMITTER: Kumar A 

PROVIDER: S-EPMC5045679 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature