The effect of vitamin D supplementation on knee osteoarthritis, the VIDEO study: a randomised controlled trial.

ABSTRACT:

Objective

Epidemiological data suggest low serum 25-hydroxyvitamin D₃ (25-OH-D₃) levels are associated with radiological progression of knee osteoarthritis (OA). This study aimed to assess whether vitamin D supplementation can slow the rate of progression.

Method

A 3-year, double-blind, randomised, placebo-controlled trial of 474 patients aged over 50 with radiographically evident knee OA comparing 800 IU cholecalciferol daily with placebo. Primary outcome was difference in rate of medial joint space narrowing (JSN). Secondary outcomes included lateral JSN, Kellgren & Lawrence grade, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain, function, stiffness and the Get up and Go test.

Results

Vitamin D supplementation increa

SUBMITTER: Arden NK 

PROVIDER: S-EPMC5045720 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature