Gut Microbiome Associates With Lifetime Cardiovascular Disease Risk Profile Among Bogalusa Heart Study Participants.

ABSTRACT:

Rationale

Few studies have systematically assessed the influence of gut microbiota on cardiovascular disease (CVD) risk.

Objective

To examine the association between gut microbiota and lifetime CVD risk profile among 55 Bogalusa Heart Study participants with the highest and 57 with the lowest lifetime burdens of CVD risk factors.

Methods and results

16S ribosomal RNA sequencing was conducted on microbial DNA extracted from stool samples of the Bogalusa Heart Study participants. α Diversity, including measures of richness and evenness, and individual genera were tested for associations with lifetime CVD risk profile. Multivariable regression techniques were used to adjust for age, sex, and race (model 1), along with body mass index (model 2) and both body mass index an

SUBMITTER: Kelly TN 

PROVIDER: S-EPMC5045790 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature