Standardized measures of lobular involution and subsequent breast cancer risk among women with benign breast disease: a nested case-control study.

ABSTRACT: Lesser degrees of terminal duct-lobular unit (TDLU) involution predict higher breast cancer risk; however, standardized measures to quantitate levels of TDLU involution have only recently been developed. We assessed whether three standardized measures of TDLU involution, with high intra/inter pathologist reproducibility in normal breast tissue, predict subsequent breast cancer risk among women in the Mayo benign breast disease (BBD) cohort. We performed a masked evaluation of biopsies from 99 women with BBD who subsequently developed breast cancer (cases) after a median of 16.9 years and 145 age-matched controls. We assessed three metrics inversely related to TDLU involution: TDLU count/mm(2), median TDLU span (microns, which approximates acini content), and median category of acini counts

SUBMITTER: Figueroa JD 

PROVIDER: S-EPMC5045857 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature