Assessing risk for preclinical β-amyloid pathology with APOE, cognitive, and demographic information.

ABSTRACT:

Introduction

Clinical trials in Alzheimer's disease are aimed at early stages of disease, including preclinical Alzheimer's disease. The high cost and time required to screen large numbers of participants for Aβ pathology impede the development of novel drugs. This study's objective was to evaluate the extent to which inexpensive and easily obtainable information can reduce the number of screen failures by increasing the proportion of Aβ+ participants identified for screening.

Methods

We used random forest models to evaluate the positive predictive value of demographics, APOE, and longitudinal cognitive rates in the prediction of amyloid pathology, measured by florbetapir PET or cerebrospinal fluid.

Results

Predicting Aβ positivity with demographic, APOE

SUBMITTER: Insel PS 

PROVIDER: S-EPMC5045949 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature