Mesenchymal Stem Cell-Based Therapy for Kidney Disease: A Review of Clinical Evidence.

ABSTRACT: Mesenchymal stem cells form a population of self-renewing, multipotent cells that can be isolated from several tissues. Multiple preclinical studies have demonstrated that the administration of exogenous MSC could prevent renal injury and could promote renal recovery through a series of complex mechanisms, in particular via immunomodulation of the immune system and release of paracrine factors and microvesicles. Due to their therapeutic potentials, MSC are being evaluated as a possible player in treatment of human kidney disease, and an increasing number of clinical trials to assess the safety, feasibility, and efficacy of MSC-based therapy in various kidney diseases have been proposed. In the present review, we will summarize the current knowledge on MSC infusion to treat acute kidney inj

SUBMITTER: Peired AJ 

PROVIDER: S-EPMC5046016 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature