Systematic review and stratified meta-analysis of the efficacy of carnosine in animal models of ischemic stroke.

ABSTRACT: Carnosine is a naturally occurring pleotropic dipeptide which influences multiple deleterious mechanisms that are activated during stroke. Numerous published studies have reported that carnosine has robust efficacy in ischemic stroke models. To further evaluate these data, we have conducted a systematic review and meta-analysis of published studies. We included publications describing in vivo models of ischemic stroke where the neuroprotective efficacy of carnosine was being evaluated through the reporting of infarct volume and/or neurological score as outcomes. Overall efficacy was evaluated using weighted mean difference random effects meta-analysis. We also evaluated for study quality and publication bias. We identified eight publications that met our inclusion criteria describing a tot

SUBMITTER: Davis CK 

PROVIDER: S-EPMC5046161 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature