Use of sildenafil or other phosphodiesterase inhibitors and risk of melanoma.

ABSTRACT:

Background

Phosphodiesterase 5A inhibitors (PDEIs), a common treatment for erectile dysfunction, were recently linked to an increased risk of melanoma.

Methods

We conducted two parallel case-control studies, using the Danish Nationwide Health Registries (DNHR) and the Kaiser Permanente Northern California (KPNC) electronic health records. Identifying men with histologically verified melanoma (cases) matched on birth year to 10 cancer-free controls, we estimated odds ratios (OR) for melanoma associated with high use of PDEIs (⩾100 tablets filled), adjusting for available confounders.

Results

We identified 7045 DNHR and 2972 KPNC cases with invasive melanoma. The adjusted OR for invasive melanoma associated with high PDEI use was 1.22 (95% confidence interval (CI), 0.99

SUBMITTER: Pottegard A 

PROVIDER: S-EPMC5046205 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature