Systematic review and meta-analysis of the impact of tumour budding in colorectal cancer.

ABSTRACT:

Background

Tumour budding is a histological finding in epithelial cancers indicating an unfavourable phenotype. Previous studies have demonstrated that it is a negative prognostic indicator in colorectal cancer (CRC), and has been proposed as an additional factor to incorporate into staging protocols.

Methods

A systematic review of papers until March 2016 published on Embase, Medline, PubMed, PubMed Central and Cochrane databases pertaining to tumour budding in CRC was performed. Study end points were the presence of lymph node metastases, recurrence (local and distal) and 5-year cancer-related death.

Results

A total of 7821 patients from 34 papers were included, with a mean rate of tumour budding of 36.8±16.5%. Pooled analysis suggested that specimens exhibiting tumo

SUBMITTER: Rogers AC 

PROVIDER: S-EPMC5046217 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature