The impact of diabetes mellitus on survival following resection and adjuvant chemotherapy for pancreatic cancer.

ABSTRACT:

Background

Diabetes mellitus is frequently observed in pancreatic cancer patients and is both a risk factor and an early manifestation of the disease.

Methods

We analysed the prognostic impact of diabetes on the outcome of pancreatic cancer following resection and adjuvant chemotherapy using individual patient data from three European Study Group for Pancreatic Cancer randomised controlled trials. Analyses were carried out to assess the association between clinical characteristics and the presence of preoperative diabetes, as well as the effect of diabetic status on overall survival.

Results

In total, 1105 patients were included in the analysis, of whom 257 (23%) had confirmed diabetes and 848 (77%) did not. Median (95% confidence interval (CI)) unadjusted overall sur

SUBMITTER: Kleeff J 

PROVIDER: S-EPMC5046218 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature