Angiogenesis-associated sequence variants relative to breast cancer recurrence and survival.

ABSTRACT:

Introduction

Breast cancer (BrCA) risk stratification using clinico-pathological biomarkers helps improve disease prognosis prediction. However, disease recurrence rates remain unfavorable and individualized clinical management strategies are needed. Consequently, we evaluated the influence of 14 sequence variants detected in IL-10, TGF-β1, VEGF, and their associated receptors as effective predictors of BrCA clinical outcomes.

Methods

Tumor DNA samples collected from 441 BrCA patients were genotyped using TaqMan-PCR. Most selected targets alter cytokine serum/plasma levels or signaling pathways. Relationships between genetic profiles and recurrence as well as disease-related mortality were evaluated using cumulative incidence curves and competing risk regression models.

R

SUBMITTER: Kidd LR 

PROVIDER: S-EPMC5046825 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature