Associations of serum LDL particle concentration with carotid intima-media thickness and coronary artery calcification.

ABSTRACT:

Background

Low-density lipoprotein particle (LDL-P) has recently been found to be a stronger predictor of cardiovascular disease (CVD) than LDL-cholesterol (LDL-C).

Objectives

Whether LDL-P is associated with subclinical atherosclerosis, independent of LDL-C, as well as other lipid measures has not been fully examined. We aimed to analyze LDL-P associations with measures of subclinical atherosclerosis.

Methods

We examined 870 Japanese men randomly selected from Kusatsu City, Shiga, Japan, aged 40-79 years from 2006-2008, free of clinical CVD and not using lipid-lowering medication. Cross-sectional associations of lipid measures with carotid intima-media thickness (cIMT) and coronary artery calcification (CAC; >0 Agatston score) were examined.

Results

LDL-P was

SUBMITTER: Zaid M 

PROVIDER: S-EPMC5047009 | biostudies-literature | 2016 Sep-Oct

REPOSITORIES: biostudies-literature