Aphasic variant of Alzheimer disease: Clinical, anatomic, and genetic features.

ABSTRACT:

Objective

To identify features of primary progressive aphasia (PPA) associated with Alzheimer disease (AD) neuropathology. A related objective was to determine whether logopenic PPA is a clinical marker for AD.

Methods

A total of 139 prospectively enrolled participants with a root diagnosis of PPA constituted the reference set. Those with autopsy or biomarker evidence of AD, and who had been evaluated at mild disease stages (Aphasia Quotient ≥85), were included (n = 19). All had quantitative language testing and APOE genotyping. Fifteen had MRI morphometry.

Results

Impaired word-finding was the universal presenting complaint in the aphasic AD group. PPA clinical subtype was logopenic (n = 13) and agrammatic (n = 6). Fluency, repetition, naming, and grammaticality rang

SUBMITTER: Rogalski E 

PROVIDER: S-EPMC5047036 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature