Synthesis of triazole-linked morpholino oligonucleotides via Cu(I) catalysed cycloaddition.

ABSTRACT: Triazole-linked morpholino ((TL)MO) oligonucleic acids were synthesised using the Cu(I) catalysed (3 + 2) azide-alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences via solid phase synthesis. UV melting experiments showed that the (TL)MO modification gives higher Tm values than the corresponding (TL)DNA modification.

SUBMITTER: Palframan MJ 

PROVIDER: S-EPMC5047124 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature