Hypernasality associated with basal ganglia dysfunction: evidence from Parkinson's disease and Huntington's disease.

ABSTRACT:

Background

Although increased nasality can originate from basal ganglia dysfunction, data regarding hypernasality in Parkinson's disease (PD) and Huntington's disease (HD) are very sparse. The aim of the current study was to analyze acoustic and perceptual correlates of velopharyngeal seal closure in 37 PD and 37 HD participants in comparison to 37 healthy control speakers.

Methods

Acoustical analysis was based on sustained phonation of the vowel /i/ and perceptual analysis was based on monologue. Perceptual analysis was performed by 10 raters using The Great Ormond Street Speech Assessment '98. Acoustic parameters related to changes in a 1/3-octave band centered on 1 kHz were proposed to reflect nasality level and behavior through utterance.

Results

Perceptual analys

SUBMITTER: Novotny M 

PROVIDER: S-EPMC5047145 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature