Cognitive Enhancement Therapy Improves Resting-State Functional Connectivity in Early Course Schizophrenia.

ABSTRACT:

Objective

Cognitive remediation is emerging as an effective psychosocial intervention for addressing untreated cognitive and functional impairments in persons with schizophrenia, and might achieve its benefits through neuroplastic changes in brain connectivity. This study seeks to examine the effects of cognitive enhancement therapy (CET) on fronto-temporal brain connectivity in a randomized controlled trial with individuals in the early course of schizophrenia.

Method

Stabilized, early course outpatients with schizophrenia or schizoaffective disorder (N = 41) were randomly assigned to CET (n = 25) or an active enriched supportive therapy (EST) control (n = 16) and treated for 2 years. Functional MRI data were collected annually, and pseudo resting-state

SUBMITTER: Eack SM 

PROVIDER: S-EPMC5047289 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature