Tuning supramolecular G-quadruplexes with mono- and divalent cations.

ABSTRACT: Supramolecular G-quadruplexes (SGQs) are formed via the cation promoted self-assembly of guanine derivatives into stacks of planar hydrogen-bonded tetramers. Here, we present results on the formation of SGQs made from the 8-(m-acetylphenyl)-2'-deoxyguanosine (mAGi) derivative in the presence of various mono- and divalent cations. NMR and HR ESI-MS data indicate that varying the cation can efficiently tune the molecularity, the fidelity and stability (thermal and kinetic) of the resulting SGQs. The results show that, parallel to the previously reported potassium-templated hexadecamer (mAGi₁₆·3K⁺), Na⁺, Rb⁺ and [Formula: see text] also promote the formation of similar supramolecules with high fidelity and molecularity. In contr

SUBMITTER: Martin-Hidalgo M 

PROVIDER: S-EPMC5047440 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature