The Role of Surface Receptor Density in Surface-Initiated Polymerizations for Cancer Cell Isolation.

ABSTRACT: Fluid biopsies potentially offer a minimally invasive alternative to traditional tissue biopsies for the continual monitoring of metastatic cancer. Current established technologies for isolating circulating tumor cells (CTCs) suffer from poor purity and yield and require fixatives that preclude the collection of viable cells for longitudinal analyses of biological function. Antigen specific lysis (ASL) is a rapid, high-purity method of cell isolation based on targeted protective coatings on antigen-presenting cells and lysis depletion of unprotected antigen-negative cells. In ASL, photoinitiators are specifically labeled on cell surfaces that enable subsequent surface-initiated polymerization. Critically, the significant determinants of process yield have yet to be investigated for this em

SUBMITTER: Lilly JL 

PROVIDER: S-EPMC5047530 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature