Integrated Classification of Prostate Cancer Reveals a Novel Luminal Subtype with Poor Outcome.

ABSTRACT: Prostate cancer is a biologically heterogeneous disease with variable molecular alterations underlying cancer initiation and progression. Despite recent advances in understanding prostate cancer heterogeneity, better methods for classification of prostate cancer are still needed to improve prognostic accuracy and therapeutic outcomes. In this study, we computationally assembled a large virtual cohort (n = 1,321) of human prostate cancer transcriptome profiles from 38 distinct cohorts and, using pathway activation signatures of known relevance to prostate cancer, developed a novel classification system consisting of three distinct subtypes (named PCS1-3). We validated this subtyping scheme in 10 independent patient cohorts and 19 laboratory models of prostate cancer, including cell lines an

SUBMITTER: You S 

PROVIDER: S-EPMC5047668 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature