Association analysis of DACT1 genetic variants and gastric cancer risk in a Chinese Han population: a case-control study.

ABSTRACT:

Purpose

Disheveled-binding antagonist of beta-catenin 1 (DACT1) is involved in tumorigenesis through influencing cell apoptosis and proliferation. We aimed to investigate the effect of three tag single-nucleotide polymorphisms (SNPs) in DACT1 (rs863091 C>T, rs17832998 C>T, and rs167481 C>T) on the occurrence of gastric cancer (GC), their association with specific clinical characteristics, and consideration of the functional relevance of GC-related SNPs.

Subjects and methods

In this hospital-based case-control study, the genotypes were acquired using the TaqMan-MGB method consisting of 602 cases and 602 controls. DACT1 messenger RNA level was evaluated in 76 paired tumoral and normal tissues using quantitative reverse transcription-polymerase chain reacti

SUBMITTER: Huang C 

PROVIDER: S-EPMC5047710 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature