Tolerability in the elderly population of high-dose alpha lipoic acid: a potential antioxidant therapy for the eye.

ABSTRACT:

Purpose

Alpha lipoic acid (ALA) is an antioxidant and iron-chelating supplement that has potential benefits for geographic atrophy in dry age-related macular degeneration as well as other eye diseases. The purpose of this study was to determine the tolerability of ALA in the elderly population.

Patients and methods

Fifteen subjects, age ≥65 years, took sequential ALA doses of 600, 800, and 1,200 mg. Each dose was taken once daily with a meal for 5 days. After each dose was taken by the subjects for 5 days, the subjects were contacted by phone, a review of systems was performed, and they were asked if they thought they could tolerate taking that dose of ALA for an extended period of time.

Results

The 600 mg dose was well tolerated. At the 800 mg dose, one subject had a

SUBMITTER: Sarezky D 

PROVIDER: S-EPMC5047711 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature