DNA methylation is differentially associated with environmental cadmium exposure based on sex and smoking status.

ABSTRACT: The adverse health effects of cadmium (Cd) are well known in human populations; however, much of what is known about biological mechanisms of Cd comes from in vitro and animal studies. The adverse health outcomes due to high levels of Cd exposure in the population of Mae Sot, Thailand have been extensively characterized. Here, for the first time, this population is being studied in an epigenetic context. The objective of this study was to characterize the association between DNA methylation markers and Cd exposure, taking into account sex and smoking differences, in an adult population at an increased risk of experiencing adverse health outcomes from high body burden of Cd. One hundred and sixty-nine residents from known exposure areas of Mae Sot, Thailand and one hundred residents from no

SUBMITTER: Virani S 

PROVIDER: S-EPMC5047795 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature