Shuyu Capsules Relieve Premenstrual Syndrome Depression by Reducing 5-HT_3AR and 5-HT_3BR Expression in the Rat Brain.

ABSTRACT: The effects of the Shuyu capsule on 5-HT_3AR and 5-HT_3BR expression in a rat model of premenstrual syndrome (PMS) depression and on 5-HT_3AR and 5-HT_3BR expression and hippocampal neuron 5-HT₃ channel current were investigated, to elucidate its mechanism of action against PMS depression. PMS depression model rats were divided into depression and Shuyu- and fluoxetine-treated groups, which were compared to control rats for frontal lobe and hippocampal 5-HT_3AR and 5-HT_3BR expression and behavior. The depressed model rats displayed symptoms of depression, which were reduced in treated and normal control rats. Frontal lobe and hippocampal 5-HT_3AR and 5-HT_3BR levels were significantly higher in the

SUBMITTER: Li F 

PROVIDER: S-EPMC5048033 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature