Genome puzzle master (GPM): an integrated pipeline for building and editing pseudomolecules from fragmented sequences.

ABSTRACT:

Motivation

Next generation sequencing technologies have revolutionized our ability to rapidly and affordably generate vast quantities of sequence data. Once generated, raw sequences are assembled into contigs or scaffolds. However, these assemblies are mostly fragmented and inaccurate at the whole genome scale, largely due to the inability to integrate additional informative datasets (e.g. physical, optical and genetic maps). To address this problem, we developed a semi-automated software tool-Genome Puzzle Master (GPM)-that enables the integration of additional genomic signposts to edit and build 'new-gen-assemblies' that result in high-quality 'annotation-ready' pseudomolecules.

Results

With GPM, loaded datasets can be connected to each other via their logical relationship

SUBMITTER: Zhang J 

PROVIDER: S-EPMC5048067 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature