Developmental effect of light deprivation on synaptic plasticity of rats' hippocampus: implications for melatonin.

ABSTRACT:

Objectives

There are few reports have demonstrated the effect of a change-in-light experience on the structure and function of hippocampus. A change-in-light experience also affects the circadian pattern of melatonin secretion. This study aimed to investigate developmental effect of exogenous melatonin on synaptic plasticity of hippocampus of light deprived rats.

Materials and methods

The effects of intracerebroventricular (ICV) injection of 2μg/5μl melatonin was evaluated on the basic and tetanized field excitatory post-synaptic potentials (fEPSPs) recorded in the hippocampal CA3-CA1 pathway of normal light-reared (LR) and dark-reared (DR) rats at 2, 4, and 6 weeks of age. Using RT-PCR and western blotting, developmental changes in the expression of melatonin receptors, MT1

SUBMITTER: Talaei SA 

PROVIDER: S-EPMC5048127 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature