1,25 (OH)₂D₃ treatment alters the granulomatous response in M. tuberculosis infected mice.

ABSTRACT: Induction of cathelicidin-mediated antimicrobial pathway against intracellular M. tuberculosis by 1,25-dihydroxyvitamin D₃ (1,25(OH)₂D₃), the active form of vitamin D, has been documented in vitro. However, in in vivo studies related to inflammatory disorders, 1,25(OH)₂D₃ has been demonstrated to induce an anti-inflammatory response. We therefore examined whether in the murine model of tuberculosis, the anti-inflammatory effects of 1,25(OH)₂D₃ would affect the outcome of M. tuberculosis infection. We show here that administration of 1,25(OH)₂D₃ to M. tuberculosis infected mice led to a change in lung granuloma architecture, characterized by a marked decrease in B cell lymphocytic aggregates.

SUBMITTER: Bhatt K 

PROVIDER: S-EPMC5048147 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature