Structure and specificity of the Type VI secretion system ClpV-TssC interaction in enteroaggregative Escherichia coli.

ABSTRACT: The Type VI secretion system (T6SS) is a versatile machine that delivers toxins into either eukaryotic or bacterial cells. It thus represents a key player in bacterial pathogenesis and inter-bacterial competition. Schematically, the T6SS can be viewed as a contractile tail structure anchored to the cell envelope. The contraction of the tail sheath propels the inner tube loaded with effectors towards the target cell. The components of the contracted tail sheath are then recycled by the ClpV AAA⁺ ATPase for a new cycle of tail elongation. The T6SS is widespread in Gram-negative bacteria and most of their genomes carry several copies of T6SS gene clusters, which might be activated in different conditions. Here, we show that the ClpV ATPases encoded within the two T6SS gene clusters

SUBMITTER: Douzi B 

PROVIDER: S-EPMC5048182 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature