Reversal of neurobehavioral social deficits in dystrophic mice using inhibitors of phosphodiesterases PDE5A and PDE9A.
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ABSTRACT:
SUBMITTER: Alexander MS
PROVIDER: S-EPMC5048211 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
Reversal of neurobehavioral social deficits in dystrophic mice using inhibitors of phosphodiesterases PDE5A and PDE9A.
Alexander M S MS Gasperini M J MJ Tsai P T PT Gibbs D E DE Spinazzola J M JM Marshall J L JL Feyder M J MJ Pletcher M T MT Chekler E L P EL Morris C A CA Sahin M M Harms J F JF Schmidt C J CJ Kleiman R J RJ Kunkel L M LM
Translational psychiatry 20160927 9
Duchenne muscular dystrophy is caused by mutations in the DYSTROPHIN gene. Although primarily associated with muscle wasting, a significant portion of patients (approximately 25%) are also diagnosed with autism spectrum disorder. We describe social behavioral deficits in dystrophin-deficient mice and present evidence of cerebellar deficits in cGMP production. We demonstrate therapeutic potential for selective inhibitors of the cGMP-specific PDE5A and PDE9A enzymes to restore social behaviors in ...[more]
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