White blood cell inflammatory markers are associated with depressive symptoms in a longitudinal study of urban adults.

ABSTRACT: Total white blood cell count (TWBCC) and percentage (%) composition of lymphocytes (PL) or neutrophils (PN) are linked to mid- and late-life depression, though sex-specific temporal relationships between those inflammatory markers and depressive symptoms remain unclear. The association between inflammation and depressive symptoms in longitudinal data on ethnically and socioeconomically diverse urban adults was examined with two hypotheses. In hypothesis 1, we examined the relationship between TWBCC, PL and PN with change in level of depressive symptoms from baseline to follow-up, stratifying by sex. In hypothesis 2, we examined reverse causality, by testing the relationship of depressive symptoms with change in TWBCC, PL and PN. Multiple linear mixed-effects regression models were performe

SUBMITTER: Beydoun MA 

PROVIDER: S-EPMC5048214 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature