No effect of glucose administration in a novel contextual fear generalization protocol in rats.

ABSTRACT: The excessive transfer of fear acquired for one particular context to similar situations has been implicated in the development and maintenance of anxiety disorders, such as post-traumatic stress disorder. Recent evidence suggests that glucose ingestion improves the retention of context conditioning. It has been speculated that glucose might exert that effect by ameliorating hippocampal functioning, and may hold promise as a therapeutic add-on in traumatized patients because improved retention of contextual fear could help to restrict its generalization. However, direct data regarding the effect of glucose on contextual generalization are lacking. Here, we introduce a new behavioral protocol to study such contextual fear generalization in rats. In adult Wistar rats, our procedure yields a

SUBMITTER: Luyten L 

PROVIDER: S-EPMC5048216 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature