Host genetics and susceptibility to congenital and childhood cytomegalovirus infection: a systematic review.

ABSTRACT:

Aim

To summarize available evidence on the role of host genetics in the susceptibility to congenital and childhood cytomegalovirus (CMV) infections by conducting a systematic review of published studies.

Methods

We searched online databases (PubMed, Web of Science, Scopus and HuGe Navigator) for relevant studies with well-defined inclusion and exclusion criteria and assessed the risk of bias using novel Confounding-Selection-Information bias score (CSI).

Results

5105 studies were initially identified, but only 5 met all the inclusion criteria and were analyzed in detail. Polymorphisms of the toll-like receptors (TLRs) and mannose-binding lectin (MBL) genes were shown to have an impact on the CMV infection in infants. Polymorphisms of the TLR2 (rs3804100, rs1898830), T

SUBMITTER: Gelemanovic A 

PROVIDER: S-EPMC5048223 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature