Short-term Effects of Risperidone Monotherapy on Spontaneous Brain Activity in First-episode Treatment-naive Schizophrenia Patients: A Longitudinal fMRI Study.

ABSTRACT: It is unclear whether abnormal spontaneous neural activation patterns found in chronic schizophrenia patients (CSP) are part of the pathogenesis of disease, consequences of chronic illness, or effects of antipsychotic treatment. We performed a longitudinal resting-state functional magnetic resonance imaging (fMRI) study in 42 treatment-naïve first-episode schizophrenia patients (FESP) at baseline and then after 8-weeks of risperidone monotherapy, and compared the findings to 38 healthy volunteers. Spontaneous brain activity was quantified using the fractional amplitude of low-frequency fluctuations (fALFF) and regional homogeneity (ReHo) and compared between patients and controls. Pretreatment, patients exhibited higher fALFF in left caudate compared with controls. After treatment, patient

SUBMITTER: Hu ML 

PROVIDER: S-EPMC5048418 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature