Structural Brain Abnormalities in Youth With Psychosis Spectrum Symptoms.

ABSTRACT:

Importance

Structural brain abnormalities are prominent in psychotic disorders, including schizophrenia. However, it is unclear when aberrations emerge in the disease process and if such deficits are present in association with less severe psychosis spectrum (PS) symptoms in youth.

Objective

To investigate the presence of structural brain abnormalities in youth with PS symptoms.

Design, setting, and participants

The Philadelphia Neurodevelopmental Cohort is a prospectively accrued, community-based sample of 9498 youth who received a structured psychiatric evaluation. A subsample of 1601 individuals underwent neuroimaging, including structural magnetic resonance imaging, at an academic and children's hospital health care network between November 1, 2009, and November 3

SUBMITTER: Satterthwaite TD 

PROVIDER: S-EPMC5048443 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature